CeRéMAIA
French Reference Center for rare Auto-Inflammatory Diseases and Amyloidosis
     
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Current studies

Clinical studies | Fundamental research | Publications of the CeRéMAIA

 

Clinical studies

• Beta confident CACZ885D2401
Summary of the study: Clinical results and innocuousness: a study of registered patients on ILARIS (canakinumab)
Diseases concerned: CAPS, FMF, Erdheim Chester
Financing: NOVARTIS
Project design: NOVARTIS
Principal investigator: Isabelle KONE-PAUT
Associate investigators: Tu-Anh TRAN, Isabelle MARIE
Person to contact: Isabelle MARIE (Tel : 00 33 1 45 21 63 08 )

• CACZ885D2307E1 (ended inclusions)
Summary of the study: Extension of the main study CACZ885D2307: Treatment by anti-IL1 monoclonal antibodies of patients under 4 years of age suffering from genetically confirmed CAPS
Diseases concerned: CAPS
Financing: NOVARTIS
Project design: NOVARTIS
Principal investigator: Isabelle KONE-PAUT
Associate investigators: Caroline GALEOTTI, Linda ROSSI-SEMERANO, Isabelle MARIE
Person to contact: Isabelle MARIE (Tel: 00 33 1 45 21 63 08 )

• Epidemiology of Henoch-Schönlein purpura in the Val-de-Marne department of France
Summary of the study: Estimation of the incidence of Henoch-Schönlein purpura among children in the department of Val de Marne using a capture-recapture method.
Disease concerned: Henoch-Schönlein purpura
Financing: SOFREMIP
Project designer and manager: Alfred MAHR (CHU Saint Louis Paris)
Principal investigator: Maryam PIRAM
Person to contact: Maryam PIRAM (Tel : 00 33 1 45 21 31 46)

• EUROFEVER
Summary of the study: European register for auto-inflammatory diseases
Diseases concerned: CAPS, recurrent fever of unknown origin, FMF, MKD, NAPS12, PFAPA, TRAPS, Behçet’s disease, BLAU, CRMO, DIRA, PAPA
web address: http://www.printo.it/eurofever
Financing: PRINTO
Project design: PRINTO
Principal investigator: Isabelle KONE-PAUT
Associate investigators: Véronique HENTGEN, Isabelle TOUITOU, Caroline GALEOTTI, Severine GUILLAUME-CZITROM, Maryam PIRAM, Linda ROSSI-SEMERANO, Tu-Anh TRAN, Martha DARCE BELLO, Isabelle MARIE
Persons to contact: Isabelle KONE-PAUT (Tel : 00 33 1 45 21 32 47), Martha DARCE BELLO (Tel : 00 33 1 45 21 72 52), Isabelle MARIE (Tel : 00 33 1 45 21 63 08 )
For more information

• JIR cohorte
Summary of the study: This international cohort is dedicated to collect prospective and retrospective data on juvenile inflammatory diseases. With it's modular construction, this cohort is able to conduct multiple clinical research projects in parallel. The centers participating to the JIR cohorte are associated to the development of the projects and to the scientific publications.
Web address: http://jir-cohort.ocqm.org/
Diseases concerned: AJI (Oligoarticulaires, Polyarticulaires, Rhumatisme psoriatique, Spondylarthropathies, Systémiques)
Financing: Fondation Rhumatismes-Enfants-Suisse
Project design: Michael HOFER
Principal investigator: Isabelle KONE-PAUT
Associate investigators: Martha DARCE BELLO, Caroline GALEOTTI, Véronique HENTGEN, Isabelle KONE-PAUT, Céline MARSAUD, Maryam PIRAM, Linda ROSSI-SEMERANO
Persons to contact: Isabelle KONE-PAUT (Tel : 00 33 1 45 21 32 47)

• Pharmachild
Summary of the study: This 3-10 year project entails observing children with JIA during the course of treatment with biological agents ± MTX.
Diseases concerned: Undifferentiated, oligoarticular, polyarticular, and systemic JIA, psoriatic arthritis and spondylarthropathy.
web address: http://www.printo.it/Pharmachild/
Project design: PRINTO
Principal investigator: Isabelle KONE-PAUT
Associate investigators: Caroline GALEOTTI, Severine GUILLAUME-CZITROM, Maryam PIRAM, Linda ROSSI-SEMERANO, Isabelle MARIE
Persons to contact: Isabelle KONE-PAUT (Tel : 00 33 1 45 21 32 47), Martha DARCE BELLO (Tel : 00 33 145217252), Isabelle MARIE (Tel : 00 33 1 45 21 63 08 )
For more information

• STRIVE
Summary of the study: Register of patients taking Humira and/or Methotrexate
Diseases concerned: Oligoarticular and Polyarticular JIA, and psoriatic arthritis
Financing: ABBOTT
Project design: ABBOTT
Principal Investigator: Isabelle KONE-PAUT
Associate investigators: Severine GUILLAUME-CZITROM, Linda ROSSI-SEMERANO, Tu-Anh TRAN, Isabelle MARIE
Person to contact: Isabelle MARIE (Tel : 00 33 1 45 21 63 08 )

 

Fundamental research

• Study of the expression of genes linked to TRAPS and FMF
Summary of the study: https://umai-montpellier.fr/recherche.html
Diseases concerned: FMF, TRAPS
Principal Investigator: Sylvie GRANDEMANGE
Associate investigator: Isabelle TOUITOU
Person to contact: Sylvie GRANDEMANGE (Tel : 00 33 4 99 63 60 68)

• Study of the genetic component of Behçet's disease
Summary of the study: https://umai-montpellier.fr/EN/behcet.html
Disease concerned: Behçet's disease
Principal investigator: Mouna BARAT-HOUARI
Associate investigators: Isabelle TOUITOU, Isabelle KONE-PAUT
Person to contact: Mouna BARAT-HOUARI (Tel : 00 33 4 67 33 61 52)

• Study of the transcripts and cytokinetic profile of hereditary recurrent fevers (HRFs)
Summary of the study:
      1/identification of new genes implicated in HRFs
      2/study of the expression of genes and cytokinetic profile of HRFs
Diseased concerned: CAPS, DITRA, Recurrent fevers of unknown origin, FMF, MKD, NAPS12, PFAPA, TRAPS
Financing: French national medical research institute: INSERM
Principal investigator: Serge AMSELEM (Armand-Trousseau children's hospital)
Associate investigator: Véronique HENTGEN
Person to contact: Véronique HENTGEN (Tel : 00 33 1 39 63 86 25)

• Study of the role regulatory T lymphocytes CD4+CD25+FoxP3+CD127- in the physiopathology of Behçet's disease in children
Summary of the study: Is there a quantitative and/or functional anomaly in plasma Tregs in patients with Behçet's disease?
Disease concerned: Behçet's
Financing: CIRC/Association Française de la Maladie de Behçet (National Behçet's disease association)
Principal investigator: Tu-Anh TRAN
Associate investigators: Isabelle KONE-PAUT
Person to contact:: Tu-Anh TRAN (Tel : 00 33 1 45 21 32 45)
For more information

• Study of the transcriptome of Behçet's disease
Disease concerned: Behçet's
Principal investigator: Isabelle KONE-PAUT
Associate investigator: Tu-Anh TRAN
Person to contact: Isabelle KONE-PAUT (Tel : 00 33 1 45 21 32 47)

• Infevers
Summary of the study: https://infevers.umai-montpellier.fr/web/
Diseases concerned: AIFEC, APLAID, BLAU, CAPS, Cherubism, DADA2, DIRA, DITRA, FMF, H syndrome, HYDM1, IL10 deficiency, IL10R1 deficiency, IL10R2 deficiency, JMP/NNS/CANDLE, Majeed syndrome, MKD/DSAP/RP, NAPS12, PAPA, PBMEI, SAVI, TRAPS, TRAPS11...
Financing: FP5 and DHOS (Ministry of Health Directorate for Hospitalization and Organization of Care)
Principal investigator: Isabelle TOUITOU
Associate Investigator: Florian MILHAVET
Personto contact: Isabelle TOUITOU (Tel : 00 33 4 67 33 58 59)
For more information

 

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